Plinest Polynucleotides
Cellular repair for under-eye, face, or both combinedRepair signalled at the source
Polynucleotides are purified DNA fragments injected into the dermis, where they act as biological signals that prompt fibroblasts to produce collagen and elastin. They are not fillers — they don't add volume. They work on the quality and resilience of the skin itself. At Peonella we use Plinest by Mastelli, made with highly purified PN-HPT polynucleotides, and Plinest Eye for the delicate periocular area.
Sessions take thirty to forty-five minutes. The product is delivered through fine needles or a cannula, with topical anaesthetic available on request. Most clients describe it as mild pinpricks.
A course of three sessions, two to four weeks apart, is the standard protocol. Results build over eight to twelve weeks. Single top-ups every three to six months maintain the foundation.
Particularly useful for tired, crepey under-eye skin, acne scarring, sun damage, post-laser recovery, and thin or fragile skin. A consultation confirms whether you're a good candidate.
Treatment in progress — clinical result photos in the gallery below.
Purified polynucleotides are injected into the dermis, where they act as biological signals to the surrounding cells.
The signals stimulate fibroblast activity, reduce inflammation and trigger the skin's own regenerative pathways across the treated area.
Over four to six weeks the underlying skin structure repairs. Best results come from a course of three sessions spaced two to four weeks apart.