Beauty · Injectables

Plinest Polynucleotides

We use Plinest and Plinest Eye by Mastelli, the original polynucleotide. Cellular repair for face, under-eye, or both combined in one appointment. All sessions bookable directly. New to injectables or unsure which to book? Book a free 30-minute consultation.

Plinest Polynucleotides

Cellular repair for under-eye, face, or both combined
Polynucleotides

Repair signalled at the source

Polynucleotides are purified DNA fragments injected into the dermis, where they act as biological signals that prompt fibroblasts to produce collagen and elastin. They are not fillers — they don't add volume. They work on the quality and resilience of the skin itself. At Peonella we use Plinest by Mastelli, made with highly purified PN-HPT polynucleotides, and Plinest Eye for the delicate periocular area.

Sessions take thirty to forty-five minutes. The product is delivered through fine needles or a cannula, with topical anaesthetic available on request. Most clients describe it as mild pinpricks.

A course of three sessions, two to four weeks apart, is the standard protocol. Results build over eight to twelve weeks. Single top-ups every three to six months maintain the foundation.

Particularly useful for tired, crepey under-eye skin, acne scarring, sun damage, post-laser recovery, and thin or fragile skin. A consultation confirms whether you're a good candidate.

Polynucleotides treatment

Treatment in progress — clinical result photos in the gallery below.

How it works
1
DNA-fragment signals

Purified polynucleotides are injected into the dermis, where they act as biological signals to the surrounding cells.

2
Fibroblasts activate

The signals stimulate fibroblast activity, reduce inflammation and trigger the skin's own regenerative pathways across the treated area.

3
Tissue rebuilds

Over four to six weeks the underlying skin structure repairs. Best results come from a course of three sessions spaced two to four weeks apart.

New to Peonella
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Already use Fresha? Book your session below

Plinest Eye — Under-eye

Cellular repair for the delicate tear-trough and lower-eyelid area. Specialist lighter formulation designed for thin periorbital skin.

Single session · 30 min
No commitment — pay as you go
£240
Course of 3 · 30 min
Save £36 · £228 per session
Recommended
£684
was £720
Select a session to continue

Plinest — Face

Standard polynucleotides protocol across the full face. Skin quality, texture, and density across cheeks, forehead and jawline.

Single session · 60 min
No commitment — pay as you go
£330
Course of 3 · 60 min
Save £49 · £314 per session
Recommended
£941
was £990
Select a session to continue

Plinest — Face & Eyes

Both areas treated in a single appointment. One visit, one recovery, lower total than booking separately.

Single session · 75 min
No commitment — pay as you go
£460
Course of 3 · 75 min
Save £69 · £437 per session
Recommended
£1,311
was £1,380
Select a session to continue
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What our clients say

What our clients say about Peonella — reviews posted to Fresha and Google.

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Polynucleotides — common questions

How are these different from filler?

Filler adds volume to a specific area. Polynucleotides don't add anything — they stimulate your skin's own repair process. There's no "filler look" or volume change. The improvement is in skin quality.

What are they made from?

Polynucleotides are short DNA fragments derived from purified marine sources — the molecules are biocompatible with human tissue, which is why they work so well. The active ingredient is the DNA fragments themselves, not any protein, so allergy risk is extremely low. We screen for it at consultation either way.

Will they fix my dark circles?

Polynucleotides under-eye are often the right call for genuine tear-trough hollows, thin under-eye skin, and pigmentation contributed by skin thinning. They won't fix dark circles caused purely by sleep, blood vessels, or pigmentation — we'll be honest at consultation.

Why 3 sessions?

Polynucleotides work through cumulative stimulation. One session shows mild improvement; three sessions across 2–4 weeks each is what produces the visible repair. Single sessions are useful for top-up after a course.

Can I combine with Profhilo?

Yes — they target different things. Some clients have polynucleotides for repair (e.g. under-eye), then Profhilo for general hydration. We plan timing at consultation to give each its space.

Am I a good candidate?

Most healthy adults are. We rule out pregnancy, breastfeeding, active autoimmune flare, current acute illness, and confirmed allergy to the product. Full screening at consultation.